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IACRF Research
Translational Cancer Research
Advancing cancer research through multidisciplinary science, precision oncology, molecular diagnostics, immuno-oncology and innovative translational approaches.
Research Focus
Core Areas of Research
Our research programme focuses on understanding the biological basis of cancer and translating scientific discoveries into clinically relevant applications.
01
Cancer Biology and Biomarker Discovery
- Solid and liquid tumors.
- Molecular and computational biology tools to probe cancer signaling mechanisms.
- Identification of prognostic and predictive biomarkers for detection, prognosis and minimal residual disease / relapse monitoring.
- Device development for low-cost treatment and diagnosis of cancer.
02
Spatial Biology and Single Cell Sequencing
- Map the tumor microenvironment and heterogeneity in solid and liquid tumors.
- Develop spatial-based predictive markers for immunotherapy for Indian patients.
- Tumor heterogeneity-based development of combination treatment approaches.
03
Proteomics and Metabolomics Studies
- Study protein and metabolite levels in cancer and normal tissues.
- Study adoptive immune cell proteome and metabolome to understand the effectiveness of adoptive cell transfer efficacy.
04
Experimental Cell and Biologicals Therapy and Cancer Vaccine Program
- Develop and test therapies based on adoptive immune cell transfer and CAR-T cells.
- Development of biologicals for targeted therapy.
- Anti-cancer vaccine to boost anti-cancer immunity in neoadjuvant or adjuvant settings.
Current Research
Ongoing Research in These Areas
Our ongoing translational research programmes address emerging areas of cancer biology, precision medicine, diagnostics and therapeutic innovation.
Spatial Biology Predictive Markers
Molecular Pathogenesis of Haematological Malignancies
Lymphoma Genomics
Precision Oncology
Immuno-Oncology
Translational Cancer Research
Molecular Diagnostics
Functional Genomics
Multi-Omics Integration
Cancer Nanotechnology
Research Projects
Projects in Translational Cancer Research
Selected projects focusing on cancer diagnosis, biomarkers, treatment response, genomics, immunology and innovative technologies.
Markers for Pathological Complete Response (PCR) in Triple Negative Breast Cancer (TNBC) using Spatial Biology.
Molecular mechanisms driving tumor heterogeneity in GI tract malignancies.
Hyperthermia as a potent radiosensitizer, chemosensitizer, and immunomodulator for HNCs.
Genomic and Immunophenotypic Landscape of B- and T-Cell Lymphomas in an Indian Cohort.
Impact of Tumor Hypoxia on Cytotoxic T-Lymphocyte Differentiation and Function in Tongue Squamous Cell Carcinoma.
Radiogenomic Markers for Glioma and Breast Cancer.
Early-stage cervical cancer diagnosis based on a novel Point-of-Care (POC) device.
Early detection of Triple Negative Breast Cancer (TNBC) by an Electrochemical Biosensor.
Molecular MRD Detection in Acute Leukemia (ALL and AML).
Predictive Biomarkers for HPV-Associated Cervical Transformation.
Funding & Grants
Extramural Grants
Extramural research grants received during the past five years.
| S. No. | Grant Title | Year | Name of Grantor | Status |
|---|---|---|---|---|
| 1 | Multimodal AI for Cancer Diagnosis and Treatment Using Radiology and Pathology | 2026 | ANRF-AISE | Ongoing |
| 2 | OncoWave: Precision Deep Hyperthermia Oncology Device for Head and Neck Cancers (HNCs) - A potent radiosensitizer, chemosensitizer, and immunomodulator for HNCs | 2026 | ANRF | Ongoing |
| 3 | Centre for Radiogenomics Research in Oncology for Theranostics Advancements | 2026 | ICMR | Ongoing |
Scientific Output
Publications
Selected publications received during the past five years.
2026
Surendran HP, Gopisetty G, Rajappa SJ, Rao TS, Unnikrishnan MK. Efficacy, safety, and characteristics of adoptive tumor-infiltrating lymphocyte therapy in solid tumours: a systematic review and meta-analysis. Front Oncol. 2026;16:1859306. doi:10.3389/fonc.2026.1859306
2026
Pasha A, Velingkar A, Sharma R, et al. Diffuse large B-cell lymphoma: from molecular stratification to precision immunotherapy. Cells. 2026;15(13):1188. doi:10.3390/cells15131188
2026
Othayoth R, Sarkar O. Nanoparticle-based precision modeling of primary and three-dimensional cell culture in cancer theranostics. Oncol Transl Med. Published online 2026. doi:10.1097/ot9.0000000000000151
2026
Dontiboina HK, Gopisetty G, Arunachalam K. Pilot study on microwave preclinical system for targeted delivery of fractionated hyperthermia in murine solid tumors. Sci Rep. 2026;16:62731. doi:10.1038/s41598-026-62731-9
2026
Heavican-Foral TB, Li Y, Lone W, et al. Tet2 deficiency alters CD4+ T cell function and promotes T cell lymphoma with a TFH cell immunophenotype. J Exp Med. 2026;223(6):e20250194. doi:10.1084/jem.20250194
2026
Sharma R, Kudithipudi J, Singh H, Prabhu D, Vuree S. In silico identification of deleterious NT5C2 and PRPS1 mutations driving thiopurine resistance in relapsed acute lymphoblastic leukemia. Cancer Genet. 2026;302-303:8-12. doi:10.1016/j.cancergen.2026.01.001
2024
Gadicherla R, Niraj N, Kamma S, Othayoth R. Characterization of mitochondrial DNA mutations in colorectal cancer progression by in-silico approach and use as potential biomarkers for diagnosis and prognosis. Egypt J Med Hum Genet. 2024;25(1):126. doi:10.1186/s43042-024-00599-y
2024
Arora S, Sheoran S, Govindaiah P, Vure S. Hesperidin's role in the treatment of lung cancer: in-silico and in-vitro findings. In Silico Pharmacol. 2024;12(2):104. doi:10.1007/s40203-024-00265-6
2024
Gadicherla R, Kamma S, Othayoth R. Exploring the impact of mitochondrial tRNA mutations on colorectal cancer development and their potential as biomarkers. Afr J Biol Sci. 2024;6(5):2528-2538.
2023
Othayoth R, Khatri K, Gadicherla R, Kodandapani S, Botlagunta M. Multivitamin-cisplatin encapsulated chitosan nanoparticles modulate DDX3X expression in cancer cell lines. Nano Biomed Eng. 2023;15(1):1-12. doi:10.26599/NBE.2023.9290008
2023
Botlagunta M, Khatri K, Madhavi L. Differential expression of DDX3 and microRNAs in response to hormone and cisplatin against cervical cancer. Eurasian J Med Oncol. 2023;6(4). doi:10.14744/ejmo.2023.96531
2021
Annapurna SD, Pasumarthi D, Pasha A, et al. Identification of differentially expressed genes in cervical cancer patients by comparative transcriptome analysis. BioMed Res Int. 2021;2021:8810074. doi:10.1155/2021/8810074
2020
Raghunath K, Sumathi C, Rajappa SJ, et al. Impact of naturopathy, yoga, and dietary interventions as adjuvant chemotherapy in the management of stage II and III adenocarcinoma of the colon. Int J Colorectal Dis. 2020;35(12):2309-2322. doi:10.1007/s00384-020-03711-x
Research Excellence Through Collaboration
Our research programmes bring together expertise in cancer biology, genomics, computational biology, spatial biology, immunology, diagnostics and translational medicine to advance cancer research and patient-focused innovation.
Advancing Cancer Research for Better Patient Outcomes
IACRF is committed to translating scientific discoveries into innovative approaches for cancer diagnosis, treatment and prevention.